Among the top hits, we focused on complement C3 (C3), matrix metalloprotease 3 (MMP3), C-C motif chemokine ligand 5 (CCL5), and Follistatin-like 1 (FSTL1) because these proteins have been implicated in AD pathology by previous studies [25–28], and also because well-characterized antibodies are commercially available. The gene discussed is C3; the disease is Alzheimer disease.