Notably, in genito-urinary cancer (BRCA, CESC, TCGT, and UCEC); gastrointestinal tumor (STAD); brain tumor (LGG), head, neck, and lung tumors (HNSC, LUSC, and OSCC); and tumors of other origins (ACC, PCPG, SARC, and SKCM), WDHD1 expression showed significant negative correlations with StromalScore, ImmuneScore, and EstimateScore (Fig. 8A). The gene discussed is WDHD1; the disease is brain neoplasm.