Additionally, researchers have also observed a higher WDHD1 expression in PTEN-inactive TNBC cells, human papillomavirus (HPV)-16 oncogene E7-expressing spontaneously immortalized human foreskin keratinocytes, cholangiocarcinoma cell lines, and MEL cells [17, 18, 63, 65]. This evidence concerns the gene PTEN and cholangiocarcinoma.