High WDHD1 expression was associated with poor prognosis in cancers originating from the gastrointestinal (LIHC and PAAD), lung (LUAD), brain (LGG), and tumors of other origins (ACC, MESO, and SARC), as evidenced by OS, DSS, and PFI. This evidence concerns the gene WDHD1 and adrenal cortex carcinoma.