Notably, in genito-urinary (BLCA, KICH, and KIRP), gastrointestinal (LIHC and PAAD), and brain (LGG) tumors, as well as tumors of other origins (ACC, MESO, SARC, and SKCM), WDHD1 exhibited good prognostic value, although there were scarce reports explaining its specific role in these tumors. Here, WDHD1 is linked to adrenal cortex carcinoma.