RER1 and obesity due to melanocortin 4 receptor deficiency: Multiple novel shared loci were mapped to genes implicated in alcohol intake (GIT2 and HOMER2) [38, 39], glucose metabolism or diabetes (FNIP1, PFKFB2, LINC00393, GCKR, RER1, and IGF1R) [40–43], obesity (GGNBP2, ITSN2, and FBXL17) [42, 43], biological processes related to kidney fibrosis or podocyte injury (CHCHD1, PRR12, PKP3, PPM1B, COL8A1, and ACTN4) [44–49], and endothelial function (ADAM15, RAB5A, and GAB1) [50–52], reflecting potential mechanistic pathways linking lipids to CKD.