Obesity could lead to multiorgan ectopic lipid accumulation, characterized by adipocyte hypertrophy, insulin resistance, dysregulation of inflammatory cytokines and adipokines, and stimulation of pro-inflammatory signaling pathways, which could further result in oxidative stress, inflammation, and fibrosis in the kidney, and finally triggers glomeruli and kidney tubule damage [54]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.