The mRNA transcription of TRPC3 was observed in SK-Mel-2 cells (expressing mutant NRAS), SK-Mel-187 (metastatic human melanoma cell line expressing wild-type BRAF), SK-Mel-24 (expressing mutant BRAFV600E), C8161 (metastatic human melanoma cell line expression wild-type BRAF), and HEMA-LP (melanocyte cell line). The gene discussed is NRAS; the disease is melanoma.