ORAI1 and alopecia: The authors reported that Orai1(−/−) mice were small in size, with eyelid irritation and sporadic hair loss resembling the cyclical alopecia observed in mice with keratinocyte-specific deletion of the Cnb1 gene, which encodes Calcineurin subunit Yang et al. also reported that mice with ubiquitous Orai1 deficiency show early lethality [47].