ORAI1 and metastatic melanoma: Indeed, we found that Orai1 was abundantly expressed in human primary melanoma cell lines (WM115 and WM1552 cells), human metastatic melanoma cell lines (SK-Mel-2, C8161, SK- and Mel-24 cells), a human melanocyte cell line (HEMA-LP cells) and a mouse melanoma cell line (B16 cells) [7].