In the PPI network of these Egr targets in the DG region, the top key nodes tightly associated with distinct psychiatric disorders and addictive behaviors in previous studies included Syt1, Stx1a, Dlg4, Cplx1, Gria1, Snap25, Rab3a, and Bdnf81,86–91. The gene discussed is GRIA1; the disease is psychiatric disorder.