SOD1 and amyotrophic lateral sclerosis: The progression from cerebellar signs predominating at younger ages to neuromuscular weakness being more pronounced later in disease progression in affected dogs is very similar to the progression seen in the degenerative myelopathy (SOD1 mutation, similar to human amyotrophic lateral sclerosis) in Boxers and Pembroke Welsh Corgis (Shelton et al. 2012).