FFAs cause insulin resistance and inflammation, linking obesity, insulin resistance, inflammation, T2D, dyslipidemia and atherosclerotic disease.28 Our findings of higher fasting and 2-h FFA concentrations in VLBW participants, might be a sign of insulin resistance of adipose tissue,29 i.e., insulin is not suppressing FFA formation (lipolysis) after a glucose load. Here, INS is linked to metabolic syndrome.