The most commonly damaged genes in the cardiac syndromic subset gene list included KMT2D (N = 5, Kabuki Syndrome), NOTCH1 (N = 4, Aortic Valve Disease 1), ANKRD11 (N = 3 KBG Syndrome), MED12 (N = 2, Opitz-Kaveggia Syndrome), SHANK3 (N = 2, Phelan-Mcdermid Syndrome), and SRCAP (N = 2, Floating-Harbor Syndrome). This evidence concerns the gene NOTCH1 and Phelan-McDermid syndrome.