The highest risk scores (both high PRS313 and high WIDTM-qtBC) were associated with higher tumour stages and grades (Fig. 3d, p = 0.0349 and p = 0.0167 for stage and grade, respectively, derived from logistic regression model using ER status, PR status, HER2 status, nodal stage, tumour stage, and tumour grade as independent variables and risk group as the dependent variable). Here, ESR1 is linked to neoplasm.