A combination of 313 SNPs (polygenic risk score, PRS313) has previously been reported to achieve an area under the receiver-operator curve (AUC) of 0.630 (95%CI: 0.628–0.651) overall, and 0.641 and 0.601 for estrogen receptor (ER) positive (ER+) and negative (ER-) cancers, respectively4. The gene discussed is ESR1; the disease is cancer.