RGS1 and asthma: This cluster was characterized by higher expression of leukotriene C4 synthase (LTC4S) as well as the glucocorticoid receptor associated peptidyl-prolyl cis–trans isomerase FKBP5. Moreover, regulator of G-protein signaling 1 (RGS1), a gene which is associated with auto-immune disorders and potentially also asthma in humans37,38, was higher expressed in cluster MC1.