Given the predominant composition of renal tubular cells in the renal parenchyma, it is conceivable that TGFβ1/Serpin E1-elicited senescence may be expanded slowly but persistently throughout the nephron and the whole kidney via this paracrine signaling, thus representing a final common pathway for diabetes-associated kidney injury (Fig. 7). This evidence concerns the gene TGFB1 and diabetes mellitus.