Contrary to the expression level of CCNB1, a reduced methylation level of CCNB1 was observed in most tumor tissues (BLCA, CESC, COAD, ESCA, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, SARC, TGCT, THCA, UCEC) compared with corresponding normal tissues (Fig. S1). Here, CCNB1 is linked to neoplasm.