Bivariate analysis shows HbA1c less than 7%, subjects’ understanding of hypoglycemia symptoms, duration of T2DM more than 10 years, history of severe hypoglycemia, eGFR less than 60 mL/min/1.73 m2, use of sulfonylurea, and insulin use were associated with severe hypoglycemia (Table 2). This evidence concerns the gene INS and type 2 diabetes mellitus.