As shown in Fig. 2B, TLX2 high expression showed poor PFS of ACC (HR 3.10; 95% CI 1.67–5.77; P = 0.0004), COAD (HR 1.47; 95% CI 1.03–2.11; P = 0.035), READ (HR 2.09; 95% CI 1.07–4.08; P = 0.03), and UCS (HR 3.01; 95% CI 1.54–5.92; P = 0.001). This evidence concerns the gene TLX2 and adrenal cortex carcinoma.