Of note, differently from neuroblastoma but in accordance to what was observed in myeloma [10, 11], we have here demonstrated that DNA damage, induced by SETD8 inhibition, arrests glioblastoma cell cycle progression regardless of p53 proficiency: p53-proficient cells arrest at G1/S; p53-deficient cells arrest at G2/M checkpoint. The gene discussed is KMT5A; the disease is glioblastoma.