TP53 and glioblastoma: Our data, demonstrating that the UNC0379+adavosertib combination is highly efficacious in both p53-proficient and -deficient glioblastoma cells, establish that p53 status cannot be utilized as a biomarker for predicting response, making, on the other hand, UNC0379+adavosertib treatment an option for the high percentage of glioblastomas with impaired p53 pathway [36].