We identified frequent copy number alterations, SNVs and InDels in other breast cancer driver genes previously reported to be frequently altered in HER2+ specific breast cancer (Supplementary Fig. 3; Supplementary Table 2–4) including CDK12, MYC, PIK3CA with copy number loss or somatic mutations in known tumour suppressor genes including TP53 and NF1. This evidence concerns the gene NF1 and breast cancer.