These include DNA damage-sensing kinase PRKDC, an M2 PPI that was upregulated in activity during infection (Fig. 3F) and had five upregulated phosphorylation sites upon pH1N1, H3N2 and H5N1 infection (Fig. 3G); and AHNAK, a large (~700 kDa) scaffold protein and an NEP PPI that had 11 IAV-modulated phosphorylation sites (Fig. 3G). Here, PRKDC is linked to infection.