Focusing on these proteomically detected genes with pLOF variants and looking at the average of the severe influenza disease association FDR across the three dataset tests, we find two surpassing our significance threshold (FDR < 0.1): AHNAK and SEL1L. SEL1L interacts with H3N2 HA, and while detected in both AB and PH datasets, it is not significantly regulated during IAV infection at the protein level. This evidence concerns the gene SEL1L and influenza.