Interestingly, AHNAK is identified as a significant gene with pLOF variants associated with patients who experienced severe influenza disease (Fig. 4D), regulated in protein AB and PH during cellular IAV infection (Fig. 4E, F), and contained phosphorylation disruption mutations at site serine 210 significantly associated with severe influenza disease (Fig. 4H), indicating AHNAK may play an important role in disease outcome. Here, AHNAK is linked to influenza.