Here, we focus on unc-116, the Caenorhabditis elegans ortholog of the KIF5C kinesin-1 heavy chain gene that has been implicated in NDDs including intellectual disability, epilepsy and autism (Awadalla et al., 2010; Cavallin et al., 2016; Coe et al., 2014; Jamuar et al., 2014; Kaplanis et al., 2020; Michels et al., 2017; Poirier et al., 2013; Wang et al., 2020; Willemsen et al., 2014). Here, KIF5C is linked to epilepsy.