For the ALOX12 SNPs, total colorectal polyp risk reduction by aspirin was restricted to common homozygotes, but not those with one or more minor alleles (Pint = 0.02 for rs2073438 and rs2920421, and Pint = 0.06 for rs2271316; Table 3). This evidence concerns the gene ALOX12 and polyp of large intestine.