ALOX5 and polyp of large intestine: In the negative binomial regression model, ALOX5 rs7090328 was associated with modification of the effect of aspirin, with a reduction in total colorectal polyp risk in homozygotes for the minor allele [IRR, 0.27 (0.11–0.64); P = 0.003; pFDR q = 0.05], but not in individuals with one or more major A alleles [IRR (AA), 0.81 (0.59–1.11); P = 0.2], with a Pint value of 0.03 (Table 3).