TP53 and polyp of large intestine: We also demonstrated that homozygosity for the SNP (rs104522; G>C; Arg72Pro) in the coding region of the TP53 tumor suppressor gene was associated with colorectal polyp reduction in aspirin users in the seAFOod trial, in contrast with the group of individuals that had at least one major (G) allele, who did not demonstrate a reduction in colorectal polyp risk associated with aspirin use.