ALOX5 and polyp of large intestine: Univariate analysis of individual SNPs and total colorectal polyp number in aspirin and EPA users compared with individuals who were allocated to the respective placebo intervention demonstrated statistical significance for the ALOX5 SNP rs7090328 and for three ALOX12 SNPs (rs2073438, rs2920421, and rs2271316, which were in strong LD - R2 between 0.671 and 0.871 for all pairwise comparisons), for aspirin users (Supplementary Fig. S2; Supplementary Table S2).