TP53 and polyp of large intestine: The only SNP in the panel of polymorphisms previously linked to modification of colorectal cancer risk (5, 15, 16), which demonstrated statistical significance for modification of the association of aspirin use and total colorectal polyp number, was rs104522, which is a SNP in the TP53 tumor suppressor gene (Supplementary Fig. S3; Supplementary Table S2).