For the PTGS2 SNP rs2745557, total colorectal polyp risk reduction was restricted to individuals with one or more minor (A) alleles [IRR, 0.60 (0.41–0.88); P = 0.009; pFDR q = 0.06], but not common homozygotes (Pint = 0.2; Table 2). This evidence concerns the gene PTGS2 and polyp of large intestine.