For PTGS1 rs4837960, aspirin use was associated with a reduction in total colorectal polyp risk in homozygotes for the major allele [IRR, 0.69 (0.53–0.90); P = 0.006; pFDR q = 0.06], but not in individuals with one or more minor T alleles [IRR, 0.91 (0.59–1.40); P = 0.7; Table 2]. Here, PTGS1 is linked to polyp of large intestine.