To further investigate a role for mutp53 in the overexpression of DNA2 in cancer cells, we measured the levels of DNA2 mRNA and protein after transfection of either WT p53 or one of the p53 hotspot mutants, including V143A, R175H, R248W, R249S, and R273H, in H1299 p53-null non–small cell lung cancer cell line. This evidence concerns the gene TP53 and cancer.