By pair-wise Pearson correlation analysis using GEPIA website tool with tumor data from TCGA database [39], we found that the mRNA expression level of ZCCHC8 is positively correlate with RBMX level (Fig 4A), suggesting that RBMX might regulate TERRA degradation by interacting with ZCCHC8. This evidence concerns the gene ZCCHC8 and neoplasm.