PRSS3 (serine protease, mesotrypsin) is an important enzyme in intestinal physiology, involved in metabolism of water-soluble vitamins [38, p. 1], defensin processing [39] and activation of antimicrobial response by REG3 [40] while RIPK4 has been implicated in migration of pancreatic cancer cells by inhibiting the RAF1/MEK/ERK signalling repressor PEPBP1 [41]. Here, REG3A is linked to familial pancreatic carcinoma.