Interaction analysis of the 35 top differentially expressed genes (DEG) revealed Bmp7, Ripk4, Wnt4, Timp1, Col11a1, Acp5, Vdr, Col8a1, Aldh1a1, and Thbs4 as the ten core genes in IVDD in STZ induced T1DM rats in descending enrichment [123]. Here, THBS4 is linked to type 1 diabetes mellitus.