The anorexia and protein-energy wasting observed in dialysis patients have been extensively linked to the accumulation of medium molecules and increased levels of adipokine and leptin, IL-6, TNF-α, and IL-1b, which has been associated with lower albumin and pre-albumin levels, an inverse correlation with muscle mass, and lower levels of physical endurance [65]. The gene discussed is ALB; the disease is Anorexia.