Cytoskeletal disorders include Wiskott-Aldrich syndrome (WAS), Wiskott-Aldrich syndrome protein (WASP) WAP interacting protein (WIP), Dedicator of cytokinesis 8 (DOCK8) deficiency and Serine/threonine kinase 4 (STK4) deficiency. The gene discussed is DOCK8; the disease is Wiskott-Aldrich syndrome.