PLP1 and multiple sclerosis: Interestingly, a report has shown that Hsp70 specifically interacts with PLP1 and MBP in damaged oligodendrocytes in patients with multiple sclerosis [67], and the C11orf7 C4S mutant also specifically binds to filamin A. Considering these findings, the dysfunction of the C11orf73 mutant might cause the mislocalization of MBP and PLP1 and abnormal cell morphological changes in oligodendrocytes in patients with HLD13 during development.