To the best of the author’s knowledge, the current case-control study is the first investigating the association of the three most intensively studied SNVs in VDR, namely FokI (rs222857, also known as rs10735810), TaqI (rs731236), and BsmI (rs1544410), with the susceptibility to develop migraine and diverse clinical phenotypes and features in a Southeastern European population residing in Greece. The gene discussed is VDR; the disease is migraine disorder.