IL6 and neoplasm: Notably, research by Testa and colleagues demonstrated that a ladder climbing protocol for resistance training led to decreased muscle atrophy in both the extensor digitorum longus and soleus muscles in tumor-bearing mice, which was attributed to the prevention of STAT3 phosphorylation, a reduction in IL-6, and decreased muscle lipid peroxidation mitigating loss of muscle strength, locomotion, and exploration capacity [297].