TRIM63 and neoplasm: Comparable adaptations were noted in another study in which motorized wheel running led to the downregulation of distinct muscle proteolysis markers [F-box only protein 32 (Fbxo32), Trim63, MuRF1 and beclin-1] and partially restored autophagy with improved mitochondrial function, which in turn counteracted the decline in muscle mass and strength in C26 tumor-bearing mice [279].