FBXO32 and cancer: In human cancer patients, a combination exercise protocol enhanced type II muscle fibers and the strength of the knee and elbow muscles while regulating the markers related to autophagy, the UPS system (FOXO3, MuRF1, Atrogin-1), and protein synthesis (mTOR, 3EBP1, S6rp) during chemotherapy and cancer cachexia [307].