The acceleration of skeletal muscle loss in cancer cachexia stems from the upregulation of catabolic factors, such as the ubiquitin-proteasome system, myostatin, and apoptosis-inducing factors [109], coupled with the downregulation of anabolic factors, including IGF-1 and its activation of the PI3K/Akt/mTOR signaling pathway [110]. This evidence concerns the gene IGF1 and cancer.