Luteolin, a flavonoid compound, can alter the breakdown of dietary starch, decrease food consumption, regulate antioxidant enzyme function to enhance oxidative stress management, safeguard pancreatic islet function, reverse macrophage polarization to alleviate insulin resistance caused by a high-fat diet, and provide protection for insulin secretion by β-cells to counteract the progression of diabetes [34,35]. This evidence concerns the gene INS and diabetes mellitus.