TNF and neoplasm: When evaluating the functional activity of the immune system of experimental animals, it was shown that at the stage of progressive tumor growth in the C(−) group, onco-dependent immunosuppression was observed, which was expressed as a decrease in the level of IL-1, IL-17, IFN-γ, TNF-α, IL- 10, both systemically (blood serum) and locally (skin homogenate) (Figure 3a,b).