EGFR and Alzheimer disease: The usage of edible and cation-free kiwi-derived extracellular vesicles (KEVs) loaded with Signal Transducer and Activator of Transcription 3 interfering RNA (siSTAT3), with a size of 186 nm, exhibited high stability, specificity, and cytotoxicity in vivo in EGFR over-expressing and mutant PC9-GR4-AZD1 cells (lung AD cell line with deletion in exon 19 of the EGFR gene and high sensitivity to TKIs).