Our previous genomic studies of familial and sporadic SCAD revealed TLN1, FBN1, LRP1, PHACTR1, ECM1, ADAMTSL4, LINC00310, C1orf54, MRPS21, EDN1, and AFAP1 as candidate genes for disease susceptibility [4,5,6]. The gene discussed is MRPS21; the disease is spontaneous coronary artery dissection.