Indeed, several studies showed that the Chr9p21 risk variants influence the expression of the non-coding RNA ANRIL and INK4/ARF-associated transcripts (CDKN2A, CDKN2B) [25,26,27,28,29], supporting a crucial role for cell cycle inhibition and key physiological processes, such as vascular senescence and apoptosis in atherosclerosis [24,25,26,27,28]. Here, CDKN2B-AS1 is linked to atherosclerosis.