SIRT1 and hypertensive disorder: For instance, exposure of rats to arsenic has been shown to significantly increase systolic blood pressure, impair contraction and relaxation responses in isolated aortas to Potassium chloride, Phenylephrine, and Acetylcholine, and upregulate the expression of SIRT1 and autophagy-related proteins [15], suggesting a negative effect of SIRT1-mediated autophagy on hypertension.