In a mouse model of myocardial infarction, Tongguan capsule has been demonstrated to promote autophagy by increasing the expression of SIRT1, reducing the phosphorylation of mTOR and its downstream effectors, namely 70 kDa ribosomal protein S6 kinase and 4E binding protein 1, and preventing the inflammation and apoptosis of myocardial cells, thereby improving cardiac remodeling [148]. This evidence concerns the gene SIRT1 and myocardial infarction.