Finally, transplant experiments in mice by using isolated cardiac progenitors’ cells derived from mouse embryonic stem cells (mESC), treated with the hormone and cardiokine Fibronectin Type III Domain-Containing 5 (Irisin), promote CMs proliferation in the injured area, attenuating myocardial fibrosis, promoting regeneration and neovascularization. Here, FNDC5 is linked to Myocardial fibrosis.