Based on the Cox proportional hazard analyses results, the effect of two IgG ratios (e.g., IgG-EBA140/IgG-DBL1-2; IgG-EBA175/IgG-DBL1-2) and one IgG1 ratio (e.g., IgG1 to MSP142/IgG1 to DBL1-2) were evaluated, but none for IgG3 since IgG3 levels to both DBL1-2 and DBL3-4 were not significantly associated with malaria risk. This evidence concerns the gene IGHG3 and malaria.