TNFRSF1A and cancer: An enzyme upregulated by cancer cells is squalene synthase (SQS), which mediates cholesterol synthesis and the buildup of tumor necrosis factor receptor 1 (TNFR1) in the lipid rafts, can induce either apoptosis or proliferation depending on the environmental context, as well as NF-κB and MAP kinase activation [28,41].