In the present study, we verified that PMNs can release NETs in an in vitro alkaline environment, and based on the important role of NETs in stimulating neovascularization after corneal alkali burns, we constructed a novel filipin chitosan nanoparticle hydrogel loaded with deoxyribonucleic acid enzymes (SCD) and conducted a preliminary exploration of its physicochemical properties, biocompatibility, and ability to regulate NETs as a biomaterial. The gene discussed is SCD; the disease is burn.