The relationship between hyperinsulinemia and overweight is therefore bidirectional: Joslowski et al. analyzed a cohort of 91 obese young adults finding that, after a follow-up of 120 days, patients with higher insulin demand caused by a less balanced diet had a minor weight reduction; the authors hypothesized that a lower insulin demand related to food intake could facilitate weight loss, but their statistical analysis did not confirm a correlation between insulin and body fat mass [17]. The gene discussed is INS; the disease is hyperinsulinism.