The outcome of the MR analysis was also consistent; namely, higher methylation at the cg05228408 site was associated with higher levels of CLCN6 (B = 0.81, p = 3.0 × 10−42, Figure 2), and consequently, this was associated with a lower risk of hypertension (B = −0.02, p = 2.4 × 10−18, Figure 2). Here, CLCN6 is linked to hypertensive disorder.