The role of LTBP3-TGF-β signaling in the differentiation of cardiac progenitor cells and formation of the heart has been researched [18]; besides, the LTBP3 pathogenic variants are reported to predispose individuals to thoracic aortic aneurysms and aortic dissections [19]. This evidence concerns the gene TGFB1 and thoracic aortic aneurysm.