In this context, the cross-talk between depression and oxidative stress/inflammation, particularly the role of nuclear factor erythroid 2-related factor 2 (Nrf2) and its target genes, has emerged as an attractive area of investigation Numerous studies have established the association between increased interleukin-6 (IL-6) levels and depression [4]. The gene discussed is NFE2L2; the disease is depressive symptom measurement.