In the striatum of rats with PD, HTHQ at a dose of 50 mg/kg more significantly reduced Il1b (p < 0.01), Tnf (p < 0.001), and Nfkb2 (p < 0.05) mRNA content compared to HTHQ at a dose of 25 mg/kg, but less significantly reduced Il6 mRNA levels (p < 0.01). Here, IL1B is linked to Parkinson disease.