HTHQ at a dose of 50 mg/kg more effectively downregulated Il1b (p < 0.01), Tnf (p < 0.01), and Nfkb2 (p < 0.001) mRNA levels than HTHQ at a dose of 25 mg/kg in the cerebral cortex of rats with PD. Here, IL1B is linked to Parkinson disease.