PTEN and Familial prostate cancer: Other findings lend further weight to the role of this oncogenic mechanism, such as the requirement of the mTOR complex 2 for development of prostate cancer in Pten null mice [140] or the suppression of leukemogenesis in Pten null mice by concomitant deletion of Rictor (an essential component of mTORC 2) [141] (there has been a hot debate on the role of PDK1 in Akt phosphorylation at Ser473).