Finlay et al. [139] showed that “PDK1 has an obligatory function in controlling the phosphorylation and transcriptional inactivation of Foxo1, 3a and 4 in Pten-null cell” and that “Pten null T cell progenitors cannot transform or develop into invasive and fatal T lymphoma without PDK1”. The gene discussed is PDK1; the disease is lymphoma.