Since the growth-promoting effects of telomerase have been linked to TGFβ inhibition and the expression of the TGFβ effector gene JunB is decreased in mice that overexpress mTert, it is apparent that the same, or closely related, pathway as that of Beckwith–Wiedemann syndrome may be involved in this tumor model [1]. The gene discussed is TGFB1; the disease is neoplasm.