PTEN and leukemia: Moreover, Rictor deficiency in Pten null cells restored long-term reconstitution ability (of myeloid and T cells, although not B lymphoid cells), which suggests that loss of long-term reconstitution is associated with HSC mobilization (and accelerated differentiation to MPPs since Rictor deletion reduced MPP number) and, in turn, prevention of leukemia development by Rictor deletion correlates with restored repopulation efficiency due to decreased HSC mobilization and early differentiation to MPPs.