Obviously, deletion of Foxo in AML-F9 transplanted Cre+ recipient mice extended latency and survival due to differentiation-related cell death, but the majority of mice eventually succumbed to leukemia, suggesting that, independently of its effect on myeloid maturation and apoptosis, Foxo3 depletion cannot eradicate LSCs after transformation. Here, FOXO3 is linked to acute myeloid leukemia.