One way to unify the cancer pathways of mature and stem/early progenitors is to hypothesize that the common outcomes of the independent mutations that are prevalent in common adult cancers may converge in a final step of telomere attrition/dysfunction, which, similar to the crisis observed in in vitro culture, might trigger reactivation of telomerase or ALT which is indispensable for the indefinite survival of cancer cells. Here, GPT is linked to cancer.