Apart from CD117/c-Kit positivity shared with ICCs of the gastrointestinal tract, ICC-like cells present in their membrane a series of proteins (CD34, vimentin, platelet-derived growth factor receptors alpha and beta [PDGFR-α and β], caveolin-1, CD44, stem cell antigen-1 [Sca-1], Nanog and octamer-binding protein 4 [Oct-4]) that make their immunohistochemical recognition distinctive. The gene discussed is POU5F1; the disease is intrahepatic cholangiocarcinoma.