Gene variations (p.G972R, and p.T608R) of insulin receptor substrate 1 (IRS-1), PI3K and (R274H, R208 K and R467W) and in AKT2 were reported to be associated with T2D, fasting hyperglycemia and postprandial hyperinsulinemia [24]. The gene discussed is IRS1; the disease is Hyperinsulinemia.