We found that nine genes (ANXA2, CLEC4G, FTCD, GLS2, H2AFZ, IGF1, STERPINA4, STMN1, TUBA1B) showed a significant impact on the poor survival prognosis of HCC patients with a p-value ≤ 0.05. This evidence concerns the gene CLEC4G and hepatocellular carcinoma.