These genes were HSP90AA1, HSP90AB1, NCL, RANBP2, ASH1L, RPS3A, CEVPE, DNAJC3, UQCRC2, CCT8, HELLS, PRKC1, SMG1, KIF20B, ANLN, CDCA2, CHUK, CYBB, CYTIP, NAP1L1, SOD2, ACTR2, CD52, DIEXF, DNAJC21, ERC1, IL2RB, MACF1, MIB1, ROCK2 and XRN1, which may play an important role in PAH progression. This evidence concerns the gene SMG1 and pulmonary arterial hypertension.