These genes were HSP90AA1, HSP90AB1, NCL, RANBP2, ASH1L, RPS3A, CEVPE, DNAJC3, UQCRC2, CCT8, HELLS, PRKC1, SMG1, KIF20B, ANLN, CDCA2, CHUK, CYBB, CYTIP, NAP1L1, SOD2, ACTR2, CD52, DIEXF, DNAJC21, ERC1, IL2RB, MACF1, MIB1, ROCK2 and XRN1, which may play an important role in PAH progression. The gene discussed is ROCK2; the disease is pulmonary arterial hypertension.