We presumed that when co‐overexpressing LCN2/MMP9 or LOXL2/MMP9, a LCN2/LOXL2/MMP9 ternary complex synergistically degraded the matrix, which promoted the migration and invasion of ESCC cells (Fig. 5A). This evidence concerns the gene LOXL2 and esophageal squamous cell carcinoma.