SPRY2 and acute lymphoblastic leukemia: We assessed mRNA levels of these MAPK‐negative regulator genes at three stages of pre‐B NRASG12D ALL progression (pre‐B cell, early NRASG12D transduced cells and late pre‐B NRASG12D ALL cells) and observed that the expression levels of Dusp6, Etv5 and Spry2 increased upon induction of NRASG12D in early NRASG12D transduced cells compared with pre‐B cells (Figure 2E).