Previous studies have linked ALDH1A3‐mediated cancer progression to gene expression changes and ATRA [3, 5, 13], effects on epithelial‐mesenchymal‐transition [3, 10, 14], and altered glucose and gamma‐aminobutyric acid metabolism [7, 8], however, the specific factors that mediate ALDH1A3 invasion and metastasis are largely unidentified. The gene discussed is ALDH1A3; the disease is cancer.